|
T0218 |
Biperiden
|
Bipariden,Akineton,KL 373,Biperidine |
AChR
|
|
Biperiden (Bipariden) is a muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. ... |
|
T9771 |
Velufenacin
|
|
AChR
|
|
Velufenacin is an antagonist of muscarinic receptor[1]. |
|
T23297 |
(S)-(+)-Dimethindene maleate
|
|
AChR
,
Histamine Receptor
|
|
(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that inhibits muscarinic M1, M3, and M4 receptors. |
|
T16989 |
Tarafenacin D-tartrate
|
SVT-40776 D-tartrate |
Others
|
|
Tarafenacin D-tartrate is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over the M2 receptor. |
|
T13992 |
CHF5407
|
SVT-47060 |
AChR
|
|
CHF5407（SVT-47060） is a potent and selective muscarinic M3 receptor antagonist with prolonged action at muscarinic receptors.CHF5407 has an effect on bronchospasm and may be used in the study of respiratory disorders.CHF... |
|
T13385 |
Zamifenacin fumarate
|
UK-76654 fumarate |
AChR
|
|
Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor. |
|
T6364 |
Desfesoterodine
|
5-HMT,(R)-5-Hydroxymethyl Tolterodine,PNU-200577,5-HM,5-hydroxymethyl Tolterodine |
AChR
|
|
Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM. |
|
T7895 |
Syn-Ake acetate
|
Dipeptide diaminobutyroyl benzylamide |
AChR
|
|
Syn-Ake acetate (Dipeptide diaminobutyroyl benzylamide) is a muscarinic acetylcholine receptor antagonist. |
|
T10914L |
Cyclodrine
|
Cyclopent |
AChR
|
|
Cyclodrine (Cyclopent) is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist. |
|
T10914 |
Cyclodrine hydrochloride
|
|
AChR
|
|
Cyclodrine hydrochloride is a dual cholinergic muscarinic receptor (mAChR) and nicotinic receptor (nAChR) antagonist that can be used in the study of neurologically related diseases. |
|
T31207 |
GSK233705
|
Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B |
AChR
|
|
GSK233705 (Darotropium bromide) is a muscarinic receptor antagonist used in conjunction with the prevention and treatment of chronic obstructive pulmonary disease (COPD) and asthma in humans. |
|
T5655 |
MAChR-IN-1 hydrochloride
|
|
AChR
|
|
mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm. |
|
T1542 |
Pirenzepine dihydrochloride
|
Pirenzepine HCl,Bisvanil,Tabe,LS519 |
AChR
|
|
Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion. |
|
T23508 |
VU 0255035
|
|
AChR
|
|
muscarinic M1 antagonist |
|
T1534 |
Darifenacin hydrobromide
|
Darifenacin HBr,UK-88525 |
AChR
|
|
Darifenacin hydrobromide (UK-88525) is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome. |
|
T29687 |
Afacifenacin
|
Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986 |
AChR
|
|
Afacifenacin (SMP-986) fumarate is an M3 muscarinic receptor-selective antagonist used in the study of ischemic heart disease, urinary incontinence and cystitis and other disorders. |
|
T8147 |
Solifenacin
|
YM905 free base |
AChR
|
|
Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively. |
|
T28722 |
SCH 57790
|
SCH57790,SCH-57790 |
AChR
|
|
SCH 57790 is a novel and selective muscarinic M(2) receptor antagonist that releases acetylcholine and enhances cognition in experimental animals for the treatment of Alzheimer's disease. |
|
T0099 |
Tolterodine tartrate
|
Detrol LA,PNU-200583E,Kabi-2234 |
AChR
|
|
Tolterodine tartrate (PNU-200583E) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in vivo. |
|
T7079 |
Batefenterol
|
GSK961081,TD-5959 |
Adrenergic Receptor
,
AChR
|
|
Batefenterol (TD-5959) (GSK961081, TD-5959) is a muscarinic receptor antagonist and β2-adrenoceptor agonist. It displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor (Ki:1.4/1.3/3.7 nM). |
|
TP1902L1 |
G-Protein antagonist peptide acetate
|
|
Adrenergic Receptor
|
|
G-Protein antagonist peptide acetate is a truncated substance P-related peptide, competes with receptor for G protein binding. G-Protein antagonist peptide acetate inhibits the activation of Gi or Go by M2 muscarinic cho... |
|
T10000 |
(±)-Tazifylline
|
|
Histamine Receptor
|
|
(±)-Tazifylline is a selective and long-acting antagonist of histamine H1 receptor. Tazifylline shows much lower affinity for H2 receptors, α- and β-adrenoceptors, 5-hydroxytryptamine and muscarinic receptor subtypes. |
|
T60536 |
Terodiline
|
|
Calcium Channel
,
AChR
|
|
Terodiline is an orally available selective muscarinic M1 receptor and calcium channel antagonist for the study of diseases caused by abnormal bladder function. |
|
T13370 |
YM-46303
|
|
AChR
|
|
|
|
T1475 |
Fesoterodine fumarate
|
Toviaz,SPM 907 |
AChR
|
|
Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo... |
|
T1179 |
Tiotropium bromide
|
Tiopropium,BA679 BR |
AChR
|
|
Tiotropium bromide (BA679 BR) is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical a... |
|
T14345 |
Atropine methyl bromide
|
Methylatropine bromide |
AChR
|
|
Atropine methyl bromide (Methylatropine bromide) is a quaternary ammonium salt of atropine, characterized as a muscarinic receptor (mAChR) antagonist. It functions as a mydriatic to dilate the pupil during ophthalmic exa... |
|
T5051 |
Isopropamide Iodide
|
|
AChR
|
|
Isopropamide iodide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders. It also acts as a muscarinic receptor antagonist which can be applied to the t... |
|
T12489L |
Pimethixene maleate
|
Pimetixene maleate |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as we... |
|
T4494 |
CLOZAPINE N-OXIDE
|
|
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Drug Metabolite
|
|
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopa... |
|
T1006 |
Propantheline bromide
|
Neopepulsan,Pro-Banthine,Neometantyl |
AChR
|
|
Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromid... |
|
T6426 |
Buclizine dihydrochloride
|
Longifene,Buclina,Buclizine HCl,UCB-4445 |
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine dihydrochloride binds to and ... |
|
T6707 |
Tiotropium Bromide hydrate
|
BA-679 BR hydrate,BA 679BR |
AChR
|
|
Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a... |
|
T68599 |
Orphenadrine
|
Orphenadrine (free base) |
Sodium Channel
,
NMDAR
,
AChR
|
|
Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producing an IC of 0.85 μM in HEK cells.Orphenadrine is an antagoni... |
|
T38192 |
Unifiram
|
|
Others
|
|
Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra... |
|
T23124 |
PD 102807
|
|
Others
|
|
M4 muscarinic receptor antagonist |
|
T22876 |
J 104129 fumarate
|
|
Others
|
|
M3 muscarinic receptor antagonist |
|
T29047 |
UH-AH 37
|
UH-AH-37,UH-AH37 |
|
|
UH-AH 37 is a antagonist of human muscarinic acetylcholine receptor. |
|
T2278L |
Piboserod hydrochloride
|
SB 207266 hydrochloride,Piboserod HCl,SB 207266A |
|
|
Piboserod HCl is a selective antagonist of 5-HT4 and muscarinic receptor. |
|
T23379 |
Solifenacin hydrochloride
|
|
Others
|
|
Solifenacin Hcl is a muscarinic receptor antagonist. |
|
T25697L |
Levophencynonate HCl
|
Levophencynonate hydrochloride,R-(-)-Phencynonate hydrochloride |
|
|
Levophencynonate HCl is a muscarinic receptor antagonist. |
|
T2138L |
Oxyphencyclimine
|
Oxiphencycliminum,Antulcus,Zamanil,Manir,Caridan,Naridan |
|
|
Oxyphencyclimine is a muscarinic receptor antagonist (MRA) anticholinergic drug used to treat peptic ulcers. |
|
T22709 |
DAU 5884 hydrochloride
|
|
Others
|
|
muscarinic M3 receptor antagonist |
|
T23452 |
Telenzepine dihydrochloride
|
|
Others
|
|
muscarinic M1 receptor antagonist |
|
T12680 |
(±)-Darifenacin
|
(±)-UK-88525 |
Others
|
|
(±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective antagonist of M3 muscarinic receptor. |
|
T27199 |
Doxacurium Chloride
|
BW A 938U,BWA938U,Nuromax,BW-A-938U |
|
|
Doxacurium Chloride is a muscarinic acetylcholine receptor M2 antagonist. |
|
T25697 |
Levophencynonate
|
Levo-phencynonate |
|
|
Levophencynonate is a muscarinic receptor antagonist. |
|
T71014 |
Aprophit
|
|
|
|
Aprophit is a muscarinic antagonist that has been shown to selectively acylate muscarinic receptor proteins. |
|
T69234 |
Piperilate HCl
|
|
|
|
Piperilate HCl is an antispasmodic, antimuscarinic agent. It is a muscarinic cholinergic receptor antagonist. |
|
T15211 |
Elucaine
|
|
Others
|
|
Elucaine is an antagonist of the muscarinic acetylcholine receptor. It has anti-ulcerative activity. |
